I'm pretty sure we won't see much in the way of experiment (although TM has caught me out several times before now!).
I see that lots of people elsewhere are predicting a start for Bell and a back three.
I suspect we will go with a back four and the two "holding" midfielders, with Bennett, Dack, Graham and Samuel in front of Smallwood and Evans.
How about this as a slightly adjusted alternative:
Raya
Nyambe Lenihan Mulgrew Willams
Bennett Smallwood Evans Conway
Dack
Graham
?

Given that Bennett and Conway are both a-bob-each-way players, in terms of attack and defence, I reckon that line-up could work, with the relevant full-back moving up to fill the gap for whichever winger has gone into the area as an extra attacker.
Any thoughts?